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Low Dose Naltrexone

Sometimes Low Dose Naltrexone is prescribed as a part of a patient’s plan as an option for help with underlying autoimmune and inflammatory issues.  Here are several resources providing additional information on LDN.

Article:  The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain

Article:  Low-dose naltrexone for disease prevention and quality of life

Side Effects May Include:

  • Slower GI function (this is one of the ways it helps with leaky gut, celiac, and Crohn’s)  – just make sure to stay well hydrated.
  • Vivid dreams
  • Insomnia

These side effects will typically resolve on their own after a few weeks. If the insomnia was too much of a problem, rather than not taking it, we would just use it in the morning.  You would also want to stop taking it 1 week before a dental procedure or surgery requiring anesthesia or pain meds. You would also want to avoid any excessive alcohol intake, or use of narcotics while taking naltrexone.

LDN Instructions:
Take each night, preferably between 9pm and 2am.
Week 1: 1.5mg capsule, 1 each night.
Week 2: 1.5mg capsule, 2 each night.
Week 3: 4.5mg capsule, 1 each night.
4.5mg is the most common dose, with a range from 3-6mg depending on the patient.